Many people suffer from impaired folate metabolization, which is why we use a natural form of folate, Quatrefolic®, (6S)-5-Methyltetrahydrofolate glucosamine salt, in our formulas. Quatrefolic® requires no metabolic process for its activation, making it superior to all other forms of folic acid, even folate from foods. Additionally, its glucosamine salt form is 100x more structurally stable than calcium forms, which allows for exceptional bioavailability.